Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation.
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Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalMixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cellsMerlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury.p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsContribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary studyMicrotubule-mediated transport of the tumor-suppressor protein Merlin and its mutants.NHERF-1: modulator of glioblastoma cell migration and invasionGlobal Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target.EBP50 regulates the apoptosis of pancreatic cancer cells by decreasing the expression levels of Bcl-2.NHERF1/EBP50 in Breast Cancer: Clinical PerspectivesMerlin is a negative regulator of human melanoma growthMerlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathwaysDrug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 ProteinsTissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.Nuclear NHERF1 expression as a prognostic marker in breast cancer.PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss.Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2.Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cellsNHERF1 together with PARP1 and BRCA1 expression as a new potential biomarker to stratify breast cancer patients.Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.NHERF1 Between Promises and Hopes: Overview on Cancer and Prospective Openings.Na+/H+ exchanger regulatory factor 1 overexpression suppresses the malignant phenotype of MIAPaCa-2 pancreatic adenocarcinoma cells by downregulating Akt phosphorylation.
P2860
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P2860
Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Overexpression of the NF2 gene ...... h promoting PDGFR degradation.
@en
type
label
Overexpression of the NF2 gene ...... h promoting PDGFR degradation.
@en
prefLabel
Overexpression of the NF2 gene ...... h promoting PDGFR degradation.
@en
P2093
P1476
Overexpression of the NF2 gene ...... h promoting PDGFR degradation.
@en
P2093
Dan Knauer
George M Smith
Juergen-Theodor Fraenzer
Lauro Minimo
P304
P577
2003-12-01T00:00:00Z