15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.
about
The tyrosine kinase Syk regulates TPL2 activation signalsCot/tpl2 participates in the activation of macrophages by adiponectin.Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophagesSterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.PPARalpha/gamma-Independent Effects of PPARalpha/gamma Ligands on Cysteinyl Leukotriene Production in Mast CellsLipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors.Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
P2860
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P2860
15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
15-Deoxy-Delta12,14-prostaglan ...... induced by lipopolysaccharide.
@en
type
label
15-Deoxy-Delta12,14-prostaglan ...... induced by lipopolysaccharide.
@en
prefLabel
15-Deoxy-Delta12,14-prostaglan ...... induced by lipopolysaccharide.
@en
P2093
P2860
P356
P1476
15-Deoxy-Delta12,14-prostaglan ...... induced by lipopolysaccharide
@en
P2093
Cristina Rodriguez
Matilde Caivano
Philip Cohen
P2860
P304
52124-52130
P356
10.1074/JBC.M306583200
P407
P577
2003-10-13T00:00:00Z