Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
about
Mutational activation of the MAP3K8 protooncogene in lung cancerCOT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancerMolecular cloning and characterization of a conserved nuclear serine(threonine) protein kinaseAkt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformationActivation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinaseThe COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activityThe oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activationIdentification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signalingPleckstrin homology (PH) domains in signal transductionA homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersUncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivoTpl2 knockout keratinocytes have increased biomarkers for invasion and metastasisRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseMAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomasAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceExpression of mitogen-activated protein kinase pathways during postnatal development of rat heartABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responsesInvolvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C.Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages.Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.Functions of NF-kappaB1 and NF-kappaB2 in immune cell biologyExpression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells.Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activationOncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.Expression cloning of oncogenes by retroviral transfer of cDNA libraries.TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells.A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines.Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells.
P2860
Q23909570-C393A008-5910-42B3-BEA7-7873D73892DDQ24308780-746A74EE-AB7E-4977-9CF1-C0F1973A486FQ24319928-8665F949-684D-494B-B3C7-935DA5D59D3DQ24537733-F436985C-086C-49C4-9FB9-CF5CD5E924EEQ24554295-8CF4128A-DFD2-4B58-B086-C431FC23B4C7Q24562843-ABD0D794-EF83-429B-B8DA-A0E3C774694AQ24653019-349380D5-E6EA-45F5-ADB7-D72AAAFF905EQ24674848-31504D7C-5CEC-4DE9-81C0-BC809E979A7DQ28140879-81949C2F-11CF-4909-B255-E8A507273B95Q28207224-C9900F52-A409-49FE-B73B-AFD894D999BCQ28236347-74906A86-A0EC-4CEC-876D-D3F861BB9C84Q28272347-36C12897-648E-40E0-8628-574B6FA3DA7EQ28383769-0A5335B7-D101-4A04-8511-B84E4886347AQ28392041-FC3B1758-A40E-4DD2-9074-1254747FD3C6Q28392677-FC2B0598-39EE-45F9-9012-C672408AC99AQ28393224-56B7E4AB-92EC-4E0C-A8C7-AA6D54CF4F15Q28394475-17A3BF74-C739-497C-A3A2-29C85A2029F4Q28581967-96F7C485-229D-44B5-AE1A-4179AAAF1343Q28585458-48F6B557-9300-4E1E-ACF5-6F5B9D6F274EQ33599325-4D58BB7B-F5AE-495E-B3A2-69099A8461FEQ33655419-B409F723-7FFC-4E8F-A66F-E6F5BF9F9FF6Q33803841-5141C93C-C964-4691-BBB9-8E23FCC80BE4Q33848355-4FD05E31-6686-4BCF-8CC2-A54D403B868EQ35124167-3488CBEA-AE51-4FDA-8406-C1070D9CF159Q35810819-E9A29861-3949-40DF-A32E-A7714F4A2058Q35815962-978D106E-F85B-4824-B9B9-FFE44EAF7B03Q35929897-15E8031A-1B7B-4228-A680-4EE888735BCFQ36163393-1FF4E9D9-2AF0-4026-AC2D-7FAE08EFE3C0Q36229398-421DA7D3-86FF-4264-BD6C-79ED0F692049Q36566564-9F4596FA-3DBF-4E7F-A948-80F3B276D488Q37219806-C6C1AC69-C214-4E64-9524-E2CC960DCBE2Q37574047-C33C6578-0A8E-4EE8-8DBD-7A111B1DB9BFQ37635761-A06C8989-AF40-441B-8CAA-C7C2B4381212Q37995683-012305E3-D7F2-43C5-9B89-5BA77EFED485Q38300766-19ACD8C6-D9E4-4D5F-8C91-9B1912EDB2DFQ38336587-E31375AB-AD4A-45B1-B5D6-06A4FB0881E5Q38490789-0953E672-7199-4364-AF8A-419AE51D40F7Q40299856-369AFA7C-5A58-4834-BE2C-78EFF129ECAFQ40626535-4A6C0C25-6C84-459C-B57A-5C3220483F8CQ40970077-C683C4B6-90EE-49E8-B994-459FFAD79CFB
P2860
Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
description
1991 nî lūn-bûn
@nan
1991 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Structure and transforming pot ...... ding a putative protein kinase
@ast
Structure and transforming pot ...... ding a putative protein kinase
@en
Structure and transforming pot ...... ding a putative protein kinase
@en-gb
Structure and transforming pot ...... ding a putative protein kinase
@nl
type
label
Structure and transforming pot ...... ding a putative protein kinase
@ast
Structure and transforming pot ...... ding a putative protein kinase
@en
Structure and transforming pot ...... ding a putative protein kinase
@en-gb
Structure and transforming pot ...... ding a putative protein kinase
@nl
prefLabel
Structure and transforming pot ...... ding a putative protein kinase
@ast
Structure and transforming pot ...... ding a putative protein kinase
@en
Structure and transforming pot ...... ding a putative protein kinase
@en-gb
Structure and transforming pot ...... ding a putative protein kinase
@nl
P2093
P2860
P921
P356
P1476
Structure and transforming pot ...... ding a putative protein kinase
@en
P2093
P2860
P304
P356
10.1128/MCB.11.8.4088
P407
P577
1991-08-01T00:00:00Z