EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. - Wikidata - wikimedia - TriplyDB

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

http://www.wikidata.org/entity/Q40634600

about

Negative feedback regulation of the ERK1/2 MAPK pathway Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment.Flotillins in receptor tyrosine kinase signaling and cancer.Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles.Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.TumorFusions: an integrative resource for cancer-associated transcript fusions.Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.

P2860

Q28079202-C71755D3-53DA-4670-85E5-97EC32304A32 Q28591710-AA3F9D2B-0270-440D-8E28-C0F3E8579948 Q30010183-106FA5EC-4068-41E4-A1F1-AE64BBF3EBCD Q33647052-539A1CDB-2502-47DC-B325-D49C91685972 Q34526668-2077A707-44F5-40A9-848F-A3F2D3028BC5 Q35065118-57CE85D2-FD5F-457A-A4D1-FB990CD4061F Q35801918-2C81BA57-3387-435E-9764-76FF4F74DCE5 Q37152909-93A3832C-B568-488D-9526-624F01D5FB25 Q37489930-4CFF4155-287E-43DD-81BB-DA71D0F6D740 Q37693615-E8828ECA-E01C-49FD-B25F-07348030D17A Q37977174-ED8BBC79-DBDB-4190-90C8-6B671B219353 Q38086019-15552920-44A2-4BC0-A9FD-1AAA09EB3F3A Q38989457-ED1D1409-55D8-4C22-82FF-ED3887B451B4 Q40282285-DD03A0D8-8413-4160-991B-16E511780356 Q41815867-050985F2-195B-45C0-8E24-48D7910DC9DF Q47207132-28E18187-7809-499E-BB0F-4E338B393A03 Q48771028-2989218C-CEB6-40E7-94FD-370832B8F601 Q50297552-93B90B25-285D-4E63-BB29-B478942E5581 Q50297602-D410CAE9-0CED-4715-8B05-44826C2EECDF Q50297637-556FE148-44AC-48B8-AED3-E8C3292BE8AD Q50297672-0BD87026-B0EA-41E2-BFEB-3FE867D5BDB8

P2860

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

http://www.wikidata.org/entity/Q40634600

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

2003年论文

@zh

2003年论文

@zh-cn

name

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

@en

type

label

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

@en

prefLabel

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

@en

P1433

Q40634600-B6B5DBF0-912E-4A64-82C8-89B34E67B1F3

P1476

Q40634600-5DE4415D-4CC2-41AE-940D-032D84EEAE92

P2093

Q40634600-1188D4E3-A706-4377-9DFD-FC2E72F94E16

Q40634600-82694163-0C98-449C-A24A-13B00C75DAE3

Q40634600-8C9DF3E2-F99D-4748-B0D8-B8FD80898E84

P2860

Q40634600-029D60AE-E7EC-4232-B988-7FAB879EA422

Q40634600-073F2FB4-76E1-459E-AC56-34A202ABFE24

Q40634600-09B17FC9-A04D-4AA4-BD9E-B13049E68B70

Q40634600-15E952E8-169D-4FCE-B217-A8A1A8D70B43

Q40634600-189D4417-71AD-4ED1-AC27-C0B7A8BFEBF7

Q40634600-2C92D7C1-5BE3-493F-926E-C9D8439DC2E2

Q40634600-334FBCBB-60BC-4A76-84AA-E72A634E119A

Q40634600-3A109412-B47E-49D2-BB35-ABF2085C2BCC

Q40634600-4122C150-CABC-427D-B3F6-25059D193234

Q40634600-6E2D254C-8F15-40F0-9DDA-AB1C0DB624B4

P304

Q40634600-CEEF36FF-1F1A-402F-8CBF-DC446FA82814

P31

Q40634600-FE3326AB-37BD-4C07-BD91-D0248BFD6C77

P356

Q40634600-E1176948-BC28-4FE9-ACDF-384344ED8DB8

P433

Q40634600-273FE4C8-F818-4D2E-BFF7-D9C5B5A1A44C

P478

Q40634600-D3555CEB-6527-437F-B5B9-E39FA08705E3

P577

Q40634600-BD0E679B-D721-4A0B-9F63-FB147762B691

P698

Q40634600-B595D0D2-BF57-4D34-BA18-75E4A850D124

P356

P1433

Biological Chemistry

P1476

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

@en

P2093

Axel Ullrich

http://www.w3.org/2001/XMLSchema#string

Yingjie Wu

http://www.w3.org/2001/XMLSchema#string

Zhengjun Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

P304

1215-1226

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1515/BC.2003.134

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

384

http://www.w3.org/2001/XMLSchema#string

P577

2003-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12974390

http://www.w3.org/2001/XMLSchema#string