about
Ferritin light chain interacts with PEN-2 and affects γ-secretase activityToward the structure of presenilin/γ-secretase and presenilin homologsStructural biology of presenilin 1 complexesComplex regulation of γ-secretase: from obligatory to modulatory subunitsAn atomic structure of human γ-secretaseProteolytic processing of Alzheimer's β-amyloid precursor proteinPen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Structural basis of human γ-secretase assembly.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.The γ-secretase complex: from structure to function.Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.Presenilin function and gamma-secretase activity.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Toward structural elucidation of the gamma-secretase complex.Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?The many substrates of presenilin/γ-secretase.Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.The very many faces of presenilins and the γ-secretase complex.Gamma secretase inhibitors: a patent review (2013 - 2015).Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.Molecular and clinical dissection of CD24 antibody specificity by a comprehensive comparative analysis.Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor proteinStructure of the transmembrane domain of human nicastrin-a component of γ-secretase.The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.Gamma-secretase is a functional component of phagosomes.
P2860
Q24293193-BAA49460-9195-4386-8BAA-2B8F613880E2Q27002018-15438F30-D112-4575-9D5A-36BAFEE3B598Q27023904-AF1B58AA-A9DA-4776-A72E-4237528714C4Q28080576-C6009A03-C4FA-4101-961A-ED349FE25265Q28116260-E8B2C604-4A7F-43C0-B071-786CE62C931EQ28254104-84C1FD24-3D64-4C0E-95E9-3A153208C2FBQ28277779-FC0E6122-D18C-4C83-9F3B-4D2299858506Q30650829-FF394142-1303-4A40-8B03-1E8B221DD7B3Q33206144-A597FA7F-3FA3-41A1-A733-8A1004C3FBF5Q34649271-9210762B-5137-43D9-BA9C-023924E48A27Q34677532-05CF4BE0-F5EF-4AAA-8F66-73D34F48F0ABQ34752171-62721B91-CEFD-4BFF-A794-C8B77EFA1512Q35065205-89D50A0E-2B9E-45F9-B154-390FF7EC3DFAQ35658184-2F44F8E2-D7AA-42B9-A31E-C76118CBB1D0Q35986885-985DD5DA-ACA5-451D-A488-F7FEF194A34EQ36109130-A922FD01-100F-40B2-B4AF-5A24664FF828Q37108151-22896632-B2DD-4ED8-9599-4906B75BCBA2Q37140699-CA38E574-ED17-49E9-A764-2A825BBDAFE4Q37827490-C5E7B038-E780-4C77-B228-AB68ADC31988Q37845036-66444287-1D27-4785-BA99-0EEE130F70C3Q37999086-EE954674-FA9E-47A5-A6CE-97C25D562DA3Q38090514-7BDA8940-4FEC-4D54-963E-57E1C33845A1Q38738605-003B317D-2C1B-459E-B93E-34DCD1BE9E3BQ38983436-A63EAB9B-7C7C-4C4B-B3B4-5E6C9A1FCBE6Q39721191-8BBD711B-CC0C-45EB-AA7B-252D0BB5AC5DQ40165328-6A5D6C6D-0AD0-4BDD-8078-FC728FAC4E05Q40360520-D56A9754-0177-42A8-9008-801CC4FB2BEDQ40410384-C2189531-51E1-4A5C-A22D-0BF540B4A95CQ40493609-500AC6BF-BD79-4502-8259-7F11308A6F58Q40599286-330783E8-1322-42EF-9814-8F155DE770C9Q40620892-15890725-7750-4AD3-A777-51EBF8295F96Q42143882-284DA5B7-42F5-44E3-884D-F82D619E0B69Q42155167-A2CE232C-3CA1-4455-A2EA-0EB8D594FA78Q44548884-A6DAE5EC-4ADF-4F24-82E9-A800EC7E7AAEQ46652686-CBA5DC1C-47FA-4AA4-B324-EB9290BA49E0
P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Membrane topology of gamma-secretase component PEN-2.
@en
type
label
Membrane topology of gamma-secretase component PEN-2.
@en
prefLabel
Membrane topology of gamma-secretase component PEN-2.
@en
P2093
P2860
P356
P1476
Membrane topology of gamma-secretase component PEN-2.
@en
P2093
Dan Carlin
Donald S Pijak
Robert W Doms
Vanessa A Morais
Virginia M-Y Lee
P2860
P304
20117-20123
P356
10.1074/JBC.M213107200
P407
P577
2003-03-14T00:00:00Z