N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors.
about
Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiaeThrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cellsA new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteinsLysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Gα(12).FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling.G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility.Regulation and physiological functions of G12/13-mediated signaling pathways.Regulation of RhoGEF proteins by G12/13-coupled receptors.Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins.G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEFAldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt.Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12.The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells.Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.Development of an antibody fragment that stabilizes GPCR/G-protein complexes
P2860
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P2860
N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
N-terminal short sequences of ...... lective coupling to receptors.
@en
type
label
N-terminal short sequences of ...... lective coupling to receptors.
@en
prefLabel
N-terminal short sequences of ...... lective coupling to receptors.
@en
P2860
P356
P1476
N-terminal short sequences of ...... elective coupling to receptors
@en
P2093
Manabu Negishi
P2860
P304
14936-14939
P356
10.1074/JBC.M301409200
P407
P577
2003-02-19T00:00:00Z