The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
about
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylationPrenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylatedIsoprenoid modification of rab proteins terminating in CC or CXC motifsProtein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene productRhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modificationsCoassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1G protein gamma subunits with altered prenylation sequences are properly modified when expressed in Sf9 cells.Rig is a novel Ras-related protein and potential neural tumor suppressorSplice variants of SmgGDS control small GTPase prenylation and membrane localizationRhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody.Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae.Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinasesIsoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activityA protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl esterEnzymatic modification of proteins with a geranylgeranyl isoprenoid.Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acidIn vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitorsLimonene arrests parasite development and inhibits isoprenylation of proteins in Plasmodium falciparum.Platelet activation and inhibition. Novel signal transduction mechanisms.Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteinsIsoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.Inhibition of cell growth of human hepatoma cell line (Hep G2) by a farnesyl protein transferase inhibitor: a preferential suppression of ras farnesylation.Regions outside of the CAAX motif influence the specificity of prenylation of G protein gamma subunits.C-terminal CTII motif of 2',3'-cyclic nucleotide 3'-phosphodiesterase undergoes carboxylmethylation.Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells.Identification of amino acid residues required for Ras p21 target activation.Production, processing and partial purification of functional G protein beta gamma subunits in baculovirus-infected insect cells.Cyclic AMP-dependent activation of Rap1b.Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase.Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins.Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.Baculovirus expression of mammalian G protein alpha subunits.A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues.
P2860
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P2860
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
The COOH-terminal domain of th ...... n H-Ras:Rap1A chimeric protein
@en
type
label
The COOH-terminal domain of th ...... n H-Ras:Rap1A chimeric protein
@en
prefLabel
The COOH-terminal domain of th ...... n H-Ras:Rap1A chimeric protein
@en
P2093
P2860
P356
P1476
The COOH-terminal domain of th ...... n H-Ras:Rap1A chimeric protein
@en
P2093
F McCormick
G M Bokoch
L A Quilliam
P A Solski
P2860
P304
P356
10.1128/MCB.11.3.1523
P407
P577
1991-03-01T00:00:00Z