Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1
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RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humansRA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activationThe Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeletonThe RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activationMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsInsulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.Mechanism of the spatio-temporal regulation of Ras and Rap1.Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activationThe strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPasesThe Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domainCell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteinsMutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3GInteractions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDSEffect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activationRequirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesisHigh glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathwayRegulation of RasGRP via a phorbol ester-responsive C1 domain.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysRap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancerThrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysHuman papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras.Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Activation and function of the Rap1 GTPase in B lymphocytes.ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complexAntigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice.RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.Crossing paths in Human Renal Cell Carcinoma (hRCC).Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis.Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytesBiochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A.New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.CalDAG-GEFIII activation of Ras, R-ras, and Rap1.Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway.
P2860
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P2860
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1
description
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Mai 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/05/02)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/05/02)
@nl
наукова стаття, опублікована в травні 1997
@uk
name
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@ast
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@en
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@nl
type
label
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@ast
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@en
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@nl
prefLabel
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@ast
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@en
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@nl
P2093
P2860
P356
P1476
Coassociation of Rap1A and Ha- ...... -dependent activation of Raf-1
@en
P2093
K. i Kariya
M. Shirouzu
S. Yokoyama
T. Kataoka
P2860
P304
11702–11705
P356
10.1074/JBC.272.18.11702
P407
P577
1997-05-02T00:00:00Z