Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
about
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceGeneral Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide AnaloguesHepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In VitroA Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus PolymeraseAnalysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation.Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamicsMechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.Inhibition of dengue virus polymerase by blocking of the RNA tunnelBiochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.Allosteric mechanism of cyclopropylindolobenzazepine inhibitors for HCV NS5B RdRp via dynamic correlation network analysis.Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.HCV genetics and genotypes dictate future antiviral strategies.
P2860
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P2860
Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Specific inhibitors of HCV pol ...... for template/primer substrate.
@en
type
label
Specific inhibitors of HCV pol ...... for template/primer substrate.
@en
prefLabel
Specific inhibitors of HCV pol ...... for template/primer substrate.
@en
P2093
P2860
P356
P1476
Specific inhibitors of HCV pol ...... for template/primer substrate.
@en
P2093
Charles Pellerin
Daniel Lamarre
George Kukolj
Ginette McKercher
Louise Thauvette
Pierre L Beaulieu
Steven LaPlante
Sylvain Lefebvre
P2860
P304
P356
10.1093/NAR/GKH160
P577
2004-01-22T00:00:00Z