Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.
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Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinasesDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsCrystal structure of the conserved protein TT1542 fromThermus thermophilusHB8The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase foldA Novel Allosteric Inhibitor of the Uridine Diphosphate N -Acetylglucosamine Pyrophosphorylase from Trypanosoma bruceiRetention and loss of RNA interference pathways in trypanosomatid protozoansPlasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivityChemical validation of GPI biosynthesis as a drug target against African sleeping sickness.Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei.Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal ActivityKREX2 is not essential for either procyclic or bloodstream form Trypanosoma brucei.Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness.Lipid metabolism in Trypanosoma bruceiTrypanosome glycosylphosphatidylinositol biosynthesis.Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei.Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.Transcriptomic analysis of Ustilago maydis infecting Arabidopsis reveals important aspects of the fungus pathogenic mechanismsProbing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues.Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei.Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma bruceiInhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness.Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol.The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei.LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate specificity and are highly similar to proteins in Bacillus anthracis.GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei.Concerted action of diacetylchitobiose deacetylase and exo-beta-D-glucosaminidase in a novel chitinolytic pathway in the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1.The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme.The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei.Removal or maintenance of inositol-linked acyl chain in glycosylphosphatidylinositol is critical in trypanosome life cycle.Targeting the GPI biosynthetic pathway.
P2860
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P2860
Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Cloning of Trypanosoma brucei ...... an sleeping sickness parasite.
@en
type
label
Cloning of Trypanosoma brucei ...... an sleeping sickness parasite.
@en
prefLabel
Cloning of Trypanosoma brucei ...... an sleeping sickness parasite.
@en
P2093
P2860
P921
P356
P1476
Cloning of Trypanosoma brucei ...... can sleeping sickness parasite
@en
P2093
Kenneth G Milne
Maria Lucia Sampaio Güther
Terry K Smith
Tunhan Chang
P2860
P304
50176-50182
P356
10.1074/JBC.M208374200
P407
P577
2002-10-02T00:00:00Z