Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
about
A new fork for clinical application: targeting forkhead transcription factors in cancerRegulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowmentCyclins: roles in mitogenic signaling and oncogenic transformationForkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivatorsOrigin licensing and p53 status regulate Cdk2 activity during G(1).Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.Antiprogestins in gynecological diseases.PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2Deciphering the role of forkhead transcription factors in cancer therapyRegulation of CDK4Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways.New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders.Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12.MAP kinase dependent cyclinE/cdk2 activity promotes DNA replication in early sea urchin embryos.The ERK-1 function is required for HSV-1-mediated G1/S progression in HEP-2 cells and contributes to virus growthp53 protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2).The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes.Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.Inhibition of hepatic stellate cell proliferation by bone marrow mesenchymal stem cells via regulation of the cell cycle in rat.Heparin treatment of vascular smooth muscle cells results in the synthesis of the dual-specificity phosphatase MKP-1.Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation.Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways.Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2.ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression.Role of ATP in DNA synthesis of renal proximal tubule cells: involvement of calcium, MAPKs, and CDKs.Small interfering RNA against ERK1/2 attenuates cigarette smoke-induced pulmonary vascular remodeling.Oxygen-Glucose Deprivation Induces G2/M Cell Cycle Arrest in Brain Pericytes Associated with ERK Inactivation.WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
P2860
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P2860
Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Stimulation of the Raf/MEK/ERK ...... on of a nuclear-targeted CDK2.
@en
type
label
Stimulation of the Raf/MEK/ERK ...... on of a nuclear-targeted CDK2.
@en
prefLabel
Stimulation of the Raf/MEK/ERK ...... on of a nuclear-targeted CDK2.
@en
P2093
P2860
P356
P1476
Stimulation of the Raf/MEK/ERK ...... on of a nuclear-targeted CDK2.
@en
P2093
Clifford Bellone
Joseph J Baldassare
Nathan H Lents
Susan M Keenan
P2860
P304
47469-47475
P356
10.1074/JBC.M207425200
P407
P577
2002-09-30T00:00:00Z