Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
about
Discovery of natural product anticancer agents from biodiverse organismsConstituents of the Leaves and Stem Bark of Aglaia foveolata.Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia speciesPotential of plant-derived natural products in the treatment of leukemia and lymphomaTherapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae)Eukaryotic initiation factor 4F: a vulnerability of tumor cells.Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products.The relevance of higher plants in lead compound discovery programs.Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.Total synthesis of (±)-rocaglamide via oxidation-initiated Nazarov cyclization.Chinese herb derived-Rocaglamide A is a potent inhibitor of pancreatic cancer cells.Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.Fine-tuning of macrophage activation using synthetic rocaglate derivatives.Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol.The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivoDiscovery of anticancer agents of diverse natural origin.Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7.Benzofuran derivatives: a patent review.Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A.When Cancer Fights Back: Multiple Myeloma, Proteasome Inhibition, and the Heat-Shock Response.Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling.Ponapensin, a cyclopenta[bc]benzopyran with potent NF-kappaB inhibitory activity from Aglaia ponapensis.Two new lignans from twigs of Aglaia odorata.The Evolution of the Total Synthesis of Rocaglamide.Rocaglates as dual-targeting agents for experimental cerebral malaria.Novel Strategies for the Discovery of Plant-Derived Anticancer Agents
P2860
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P2860
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
@en
type
label
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
@en
prefLabel
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
@en
P2093
P2860
P356
P1476
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
@en
P2093
Bernd Baumann
Christoph Weber
Daniela Siegmund
Frank Bohnenstengel
Ingrid Herr
Peter Proksch
Thomas Wirth
P2860
P304
44791-44800
P356
10.1074/JBC.M208003200
P407
P577
2002-09-16T00:00:00Z