AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.
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The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseActivation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateMutations, kataegis and translocations in B cells: understanding AID promiscuous activityHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cellsDNA-dependent protein kinase inhibits AID-induced antibody gene conversion.A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutationA coming-of-age story: activation-induced cytidine deaminase turns 10.DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseA somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.Refining the Neuberger model: Uracil processing by activated B cells.The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma.Involvement of Rad18 in somatic hypermutationThe pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinomaSomatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Complex regulation and function of activation-induced cytidine deaminase.Class-switch recombination: after the dawn of AID.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.Overlapping hotspots in CDRs are critical sites for V region diversificationWhat role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminaseTGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex.Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.Mutagenesis by AID: Being in the Right Place at the Right Time.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesKnown components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasThe role of the non-homologous end-joining pathway in lymphocyte development.Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phaseV(H) replacement in rearranged immunoglobulin genes.AIDing antibody diversity by error-prone mismatch repair.Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines
P2860
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P2860
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
AID-dependent somatic hypermut ...... nd event in the BL2 cell line.
@en
type
label
AID-dependent somatic hypermut ...... nd event in the BL2 cell line.
@en
prefLabel
AID-dependent somatic hypermut ...... nd event in the BL2 cell line.
@en
P2093
P2860
P356
P1433
P1476
AID-dependent somatic hypermut ...... nd event in the BL2 cell line.
@en
P2093
Ahmad Faili
Barbara Bertocci
Carole Zober
Claude-Agnès Reynaud
Jean-Claude Weill
Quentin Guéranger
Said Aoufouchi
P2860
P2888
P304
P356
10.1038/NI826
P407
P577
2002-07-29T00:00:00Z
P5875
P6179
1020948149