Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
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Smurf2 up-regulation activates telomere-dependent senescenceSmall molecule compounds that induce cellular senescenceNUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stabilityRole of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stressProteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factorExpression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stressTumor suppression by p53: making cells senescent.5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activationCrosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor.Mechanism of telomerase activation by v-Rel and its contribution to transformation.Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.Stable cellular senescence is associated with persistent DDR activationFunctional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cellsES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activitySIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Telomere Q-PNA-FISH--reliable results from stochastic signals.When cells get stressed: an integrative view of cellular senescenceIncreased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state?Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene NetworksIn search of "stemness".Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans.Telomeres, telomerase, and apoptosis.AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination.The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damageRole of mitochondrial translocation of telomerase in hepatocellular carcinoma cells with multidrug resistance.Immortalized cells as experimental models to study cancer.Premature senescence of endothelial cells: Methusaleh's dilemma.Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells.Proteome alteration induced by hTERT transfection of human fibroblast cells.Sirtuins, Cell Senescence, and Vascular AgingEndogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells.Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy.Coevolution of telomerase activity and body mass in mammals: from mice to beavers.Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype.Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase.Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis.
P2860
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P2860
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Expression of human telomerase ...... nduced apoptosis and necrosis.
@en
type
label
Expression of human telomerase ...... nduced apoptosis and necrosis.
@en
prefLabel
Expression of human telomerase ...... nduced apoptosis and necrosis.
@en
P2093
P2860
P356
P1476
Expression of human telomerase ...... nduced apoptosis and necrosis.
@en
P2093
Andrei Seluanov
Olivia M Pereira-Smith
Vera Gorbunova
P2860
P304
38540-38549
P356
10.1074/JBC.M202671200
P407
P577
2002-07-24T00:00:00Z