Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
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The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial functionTreatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetesOverexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistanceIncreased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthaseDeficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistanceMuscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switchingPTG gene deletion causes impaired glycogen synthesis and developmental insulin resistanceRestoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation.Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.Maternal overweight programs insulin and adiponectin signaling in the offspring.Developmental programming of fetal skeletal muscle and adipose tissue development.Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscleInflammation and insulin resistance: an old story with new ideas.Tissue-specific insulin signaling in the regulation of metabolism and aging.Skeletal muscle stem cells from animals I. Basic cell biology.Genetic manipulation of insulin signaling, action and secretion in mice. Insights into glucose homeostasis and pathogenesis of type 2 diabetes.Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes.The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxiaLipid-induced insulin resistance: unravelling the mechanism.The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) miceInhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.The portal theory supported by venous drainage-selective fat transplantationMouse models of insulin resistance.Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.Enhanced insulin sensitivity in mice lacking ganglioside GM3.n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant miceMaternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring.Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease.In vivo mutagenesis of the insulin receptor.Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null miceLiver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease.Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
P2860
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P2860
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Redistribution of substrates t ...... insulin resistance in muscle.
@en
type
label
Redistribution of substrates t ...... insulin resistance in muscle.
@en
prefLabel
Redistribution of substrates t ...... insulin resistance in muscle.
@en
P2093
P2860
P356
P1476
Redistribution of substrates t ...... insulin resistance in muscle.
@en
P2093
F Mauvais-Jarvis
G I Shulman
M D Michael
O D Peroni
S F Previs
P2860
P304
P356
10.1172/JCI8305
P407
P577
2000-06-01T00:00:00Z