Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
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Defects in mucosal immunity leading to Crohn's diseaseThe T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancerc-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell developmentThe transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genesLymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cellsNFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expressionIL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanismsThe lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsInterleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cellsInteraction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytesAPC-derived cytokines and T cell polarization in autoimmune inflammationImmunomodulatory functions of type I interferonsCytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccinesThe role and regulation of mTOR in T-lymphocyte functionLinking obesity with type 2 diabetes: the role of T-betThe T-box gene family: emerging roles in development, stem cells and cancerThe effects of TLR activation on T-cell development and differentiationAntigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune DiseasesThe complex pathophysiology of acquired aplastic anaemiaAn updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiationCompound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cellsMolecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileSTAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cellsT-bet regulates IgG class switching and pathogenic autoantibody productionSTAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferationThe transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaIssues in T-helper 1 development--resolved and unresolvedTBX21 and HLX1 polymorphisms influence cytokine secretion at birthArid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNADifferentiation of effector CD4 T cell populations (*)Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension.Antigen presentation and the regulation of CD4 memory generation to influenza.The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4+Foxp3+ Regulatory T-CellsCD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisDownregulation of IL-13 gene transcription by T-bet in human T cells.Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisitionEffects of CD70 and CD11a in immune thrombocytopenia patients.Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cellsIkaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure
P2860
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P2860
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Distinct effects of T-bet in T ...... uction in CD4 and CD8 T cells.
@en
type
label
Distinct effects of T-bet in T ...... uction in CD4 and CD8 T cells.
@en
prefLabel
Distinct effects of T-bet in T ...... uction in CD4 and CD8 T cells.
@en
P2093
P356
P1433
P1476
Distinct effects of T-bet in T ...... uction in CD4 and CD8 T cells.
@en
P2093
Abhay R Satoskar
Barry P Sleckman
Brandon M Sullivan
Claudia Stemmann
Laurie H Glimcher
Susanne J Szabo
P304
P356
10.1126/SCIENCE.1065543
P407
P577
2002-01-01T00:00:00Z