Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
about
Mitochondrial DNA mutations in human diseaseToward a therapy for mitochondrial diseaseCentral presynaptic terminals are enriched in ATP but the majority lack mitochondriaSelective mitochondrial DNA degradation following double-strand breaksEstablishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells.Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans.Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonucleaseRe-engineering the mitochondrial genomes in mammalian cellsGene therapy for the treatment of mitochondrial DNA disorders.Cell and animal models of mtDNA biology: progress and prospects.The use of mitochondria-targeted endonucleases to manipulate mtDNAEnzymatic cleavage of type II restriction endonucleases on the 2'-O-methyl nucleotide and phosphorothioate substituted DNA.Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.Mitochondrial DNA disease: new options for prevention.Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's diseaseNear-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography.Delivery of drugs and macromolecules to mitochondria.Gene therapy of the other genome: the challenges of treating mitochondrial DNA defects.Modifying the Mitochondrial Genome.Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell poolManipulating the metazoan mitochondrial genome with targeted restriction enzymes.Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.Altering the balance between healthy and mutated mitochondrial DNA.The approaches for manipulating mitochondrial proteomeControlling subcellular delivery to optimize therapeutic effectTransduction of human recombinant proteins into mitochondria as a protein therapeutic approach for mitochondrial disorders.High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges.Inherited mitochondrial genomic instability and chemical exposures.Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.Generation of rho0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analysesInefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease.Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease.2'-O-methyl nucleotide modified DNA substrates influence the cleavage efficiencies of BamHI and BglII.The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment
P2860
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P2860
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Manipulating mitochondrial DNA ...... eted restriction endonuclease.
@en
type
label
Manipulating mitochondrial DNA ...... eted restriction endonuclease.
@en
prefLabel
Manipulating mitochondrial DNA ...... eted restriction endonuclease.
@en
P356
P1476
Manipulating mitochondrial DNA ...... eted restriction endonuclease.
@en
P2093
Srivastava S
P304
P356
10.1093/HMG/10.26.3093
P577
2001-12-01T00:00:00Z