Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.
about
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersRoles of BRCA1 in centrosome duplicationSuppression of the STK15 oncogenic activity requires a transactivation-independent p53 functionThe centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosisA positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationLinks between mutant p53 and genomic instabilityThe more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancersOccurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cellsInvolvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function.Centrosome amplification and the development of cancer.Two for two: Cdk2 and its role in centrosome doubling.Loss of p53 and centrosome hyperamplification.Centrosomal TACCtics.Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes.Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming.Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma.Mortalin controls centrosome duplication via modulating centrosomal localization of p53.Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.
P2860
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P2860
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.
description
2001 nî lūn-bûn
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2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
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2001年學術文章
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name
Difference in the centrosome d ...... ent centrosome binding of p53.
@en
type
label
Difference in the centrosome d ...... ent centrosome binding of p53.
@en
prefLabel
Difference in the centrosome d ...... ent centrosome binding of p53.
@en
P2093
P2860
P356
P1433
P1476
Difference in the centrosome d ...... ent centrosome binding of p53.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204848
P407
P577
2001-10-01T00:00:00Z
P5875
P6179
1028740064