Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program - Wikidata - wikimedia - TriplyDB

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

http://www.wikidata.org/entity/Q40784127

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Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring Translational implications of the β-cell epigenome in diabetes mellitus Epigenetic reprogramming in Mist1(-/-) mice predicts the molecular response to cerulein-induced pancreatitis Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes Epigenomic plasticity enables human pancreatic α to β cell reprogramming.Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.Dynamic regulation of epigenomic landscapes during hematopoiesis.Neuron and beta-cell evolution: learning about neurons is learning about beta-cells.Emerging patterns of epigenomic variation.A systems view of epigenetic networks regulating pancreas development and β-cell function miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets.Organogenesis and functional genomics of the endocrine pancreas Rfx6 maintains the functional identity of adult pancreatic β cells.Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.DNA methylation directs functional maturation of pancreatic β cells.Epigenetic programming of glucose-regulated insulin release.A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.Knock-down of plasminogen-activator inhibitor-1 enhances expression of E-cadherin and promotes epithelial differentiation of human pancreatic adenocarcinoma cells.REST represses a subset of the pancreatic endocrine differentiation program.Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.Polycomb and the emerging epigenetics of pancreatic cancer.Transcriptional and epigenetic dynamics during specification of human embryonic stem cells.Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.MiRNAs in β-Cell Development, Identity, and Disease.Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.Epigenetics and diabetes treatment: an unrealized promise?Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.Epigenetic regulation of pancreas development and function.Lineage determinants in early endocrine development.

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Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

http://www.wikidata.org/entity/Q40784127

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2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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Derepression of Polycomb targe ...... a neural gene activity program

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Derepression of Polycomb targe ...... a neural gene activity program

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Anouchka L Skoudy

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Harry Heimberg

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Javier García-Hurtado

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Joris van Arensbergen

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Mark Van de Casteele

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Matteo Palassini

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Miguel Angel Maestro

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Xiaobo Xu

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P2860

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes.

High-resolution profiling of histone methylations in the human genome

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Control of developmental regulators by Polycomb in human embryonic stem cells

The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells

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10.1101/GR.101709.109

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6

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20

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20395405

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2877569

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