Epigenomic plasticity enables human pancreatic α to β cell reprogramming. - Wikidata - wikimedia - TriplyDB

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

http://www.wikidata.org/entity/Q30536573

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ADCY5 couples glucose to insulin secretion in human islets Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells Transcriptional and epigenetic regulation in human islets IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells Epigenetic Regulation of Islet Development and Regeneration CEBPA exerts a specific and biologically important proapoptotic role in pancreatic β cells through its downstream network targets Adult tissue sources for new β cells.Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation Human β-cell regeneration: progress, hurdles, and controversy.Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.The Missing lnc(RNA) between the pancreatic β-cell and diabetes The pancreatic β-cell transcriptome and integrated-omics.The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.Revealing transcription factors during human pancreatic β cell development.Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.Downregulation of type II diabetes mellitus and maturity onset diabetes of young pathways in human pancreatic islets from hyperglycemic donors.Islet-1 Is essential for pancreatic β-cell function.CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD.Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.A systems view of epigenetic networks regulating pancreas development and β-cell function LKB1 and AMPK differentially regulate pancreatic β-cell identity.Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

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P2860

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

http://www.wikidata.org/entity/Q30536573

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@ast

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@en

type

label

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@ast

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@en

prefLabel

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@ast

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

@en

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Journal of Clinical Investigation

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Epigenomic plasticity enables human pancreatic α to β cell reprogramming

@en

P2093

Ali Naji

http://www.w3.org/2001/XMLSchema#string

Chengyang Liu

http://www.w3.org/2001/XMLSchema#string

Craig Dorrell

http://www.w3.org/2001/XMLSchema#string

Jonathan Schug

http://www.w3.org/2001/XMLSchema#string

Klaus H Kaestner

http://www.w3.org/2001/XMLSchema#string

Logan J Everett

http://www.w3.org/2001/XMLSchema#string

Nuria C Bramswig

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Philip R Streeter

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Yanping Luo

http://www.w3.org/2001/XMLSchema#string

P2860

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

High-resolution profiling of histone methylations in the human genome

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

Cdx2 regulates endo-lysosomal function and epithelial cell polarity

Evolution and functions of long noncoding RNAs

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1275-1284

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10.1172/JCI66514

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3582140

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