Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells
about
Regulation of p73 by Hck through kinase-dependent and independent mechanismsMyristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolaeInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayCrystal structure of a cytokine-binding region of gp130.Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorMeta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set.Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state.Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer ProgressionReceptor recognition by gp130 cytokines.p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases.Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.The paradigm of IL-6: from basic science to medicineHematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture.Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factorBone marrow microenvironment and the identification of new targets for myeloma therapy.Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells.Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune responsePreconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retinac-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.Protein kinases and associated pathways in pluripotent state and lineage differentiation.p73-Binding Partners and Their Functional Significance.Ras and signal transducer and activator of transcription (STAT) are essential and sufficient downstream components of Janus kinases in cell proliferation.Multiple myeloma: increasing evidence for a multistep transformation process.Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activationStimulation of c-Src by prolactin is independent of Jak2.
P2860
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P2860
Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells
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1994 nî lūn-bûn
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1994年の論文
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年學術文章
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1994年學術文章
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1994年學術文章
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name
Functional and biochemical ass ...... gp130 in embryonic stem cells
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type
label
Functional and biochemical ass ...... gp130 in embryonic stem cells
@en
prefLabel
Functional and biochemical ass ...... gp130 in embryonic stem cells
@en
P2093
P2860
P1433
P1476
Functional and biochemical ass ...... gp130 in embryonic stem cells
@en
P2093
P2860
P304
P407
P577
1994-04-01T00:00:00Z