p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.
about
Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 functionThe centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosisThe ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cellsThe more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancersProlonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis.Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice.Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.Centrosome amplification and the development of cancer.Control of the centriole and centrosome cycles by ubiquitination enzymes.Loss of p53 and centrosome hyperamplification.Centrosomal TACCtics.p53: guardian of ploidyEmerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cellsRegulation of therapeutic apoptosis: a potential target in controlling hypertensive organ damage.Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapyp53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replicationDNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells.Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localizationKilling of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia proteinEnhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.HEY1 functions are regulated by its phosphorylation at Ser-68.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes.p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.Cell-cycle progression without an intact microtuble cytoskeleton.P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation.DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.Mitotic Kinases and p53 Signaling.Securin a new role for itself.Mechanisms of 5-azacytidine (5AzC)-induced toxicity in the rat foetal brain.Transcriptional regulation of mitotic checkpoint gene MAD1 by p53.Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells.Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho.
P2860
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P2860
p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
p53 displacement from centroso ...... bition of the mitotic spindle.
@en
type
label
p53 displacement from centroso ...... bition of the mitotic spindle.
@en
prefLabel
p53 displacement from centroso ...... bition of the mitotic spindle.
@en
P2093
P2860
P356
P1476
p53 displacement from centroso ...... ibition of the mitotic spindle
@en
P2093
Casenghi M
Ciciarello M
D'Angelo M
Mangiacasale R
Zaira Limongi M
P2860
P304
19205-19213
P356
10.1074/JBC.M009528200
P407
P577
2001-02-28T00:00:00Z