An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele.
about
Nijmegen breakage syndrome (NBS)Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesisATMIN defines an NBS1-independent pathway of ATM signallingAccumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damageA supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damageFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionMechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exonSearching for IRESStructure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage SitesNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairXrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylationTargeted disruption of NBS1 reveals its roles in mouse development and DNA repair.Interaction of FANCD2 and NBS1 in the DNA damage responseMutations in the NDUFS4 gene of mitochondrial complex I alter stability of the splice variantsThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlFertility defects revealing germline biallelic nonsense NBN mutationsCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairA systematic proteomic study of irradiated DNA repair deficient Nbn-miceChemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cellsAn essential function for NBS1 in the prevention of ataxia and cerebellar defectsNBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiationc-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repairNibrin functions in Ig class-switch recombinationRole of RAD52 epistasis group genes in homologous recombination and double-strand break repairNBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaksMre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutationGenetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.Alternative splicing at a NAGNAG acceptor site as a novel phenotype modifier.DNA damage responses in central nervous system and age-associated neurodegenerationGenomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Productive replication of human papillomavirus 31 requires DNA repair factor Nbs1.DNA repair deficiency in neurodegeneration.DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation.Active role for nibrin in the kinetics of atm activationIsolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae.
P2860
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P2860
An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
An alternative mode of transla ...... egen breakage syndrome allele.
@en
type
label
An alternative mode of transla ...... egen breakage syndrome allele.
@en
prefLabel
An alternative mode of transla ...... egen breakage syndrome allele.
@en
P2093
P356
P1433
P1476
An alternative mode of transla ...... egen breakage syndrome allele.
@en
P2093
P2888
P304
P356
10.1038/86920
P407
P577
2001-04-01T00:00:00Z
P5875
P6179
1005326381