Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
about
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombinationCellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationEnd-resection at DNA double-strand breaks in the three domains of lifeProcessing of damaged DNA ends for double-strand break repair in mammalian cellsHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsChemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cellsCdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progressionPhosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.CtIP mediates replication fork recovery in a FANCD2-regulated manner.End resection at double-strand breaks: mechanism and regulation.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.The importance of safeguarding genome integrity in germination and seed longevity.Evidence for distinct functions of MRE11 in Arabidopsis meiosis.Regulators of homologous recombination repair as novel targets for cancer treatment.CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.Controlling DNA-end resection: a new task for CDKs.BRCA1 in the DNA damage response and at telomeresDNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy.Role of the double-strand break repair pathway in the maintenance of genomic stability.Sharpening the ends for repair: mechanisms and regulation of DNA resection.Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.CtIP/Ctp1/Sae2, molecular form fit for function.Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumoursCyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.Cell cycle-dependent control of homologous recombination.MYC Modulation around the CDK2/p27/SKP2 AxisStabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair.MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Processing of DNA double-strand break endsCell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.How cells ensure correct repair of DNA double-strand breaks.MRN complex binds CDK2 and RBBP8CDK2 phosphorylates RBBP8DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair.
P2860
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P2860
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
@en
type
label
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
@en
prefLabel
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
@en
P2093
P2860
P356
P1476
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
@en
P2093
David O Ferguson
Elizabeth Spehalski
Jeffrey Buis
Trina Stoneham
P2860
P2888
P304
P356
10.1038/NSMB.2212
P577
2012-01-08T00:00:00Z
P5875
P6179
1007242691