Assembly pathway of desmoglein 3 to desmosomes and its perturbation by pemphigus vulgaris-IgG in cultured keratinocytes, as revealed by time-lapsed labeling immunoelectron microscopy.
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The desmosomeDesmosomes in acquired diseaseLocalisation of bullous pemphigoid antigen 180 (BP180) in cultured human keratinocytes: functionally relevant modification by calcium.Adducin is required for desmosomal cohesion in keratinocytes.p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis.Desmoglein 3, via an interaction with E-cadherin, is associated with activation of SrcLoss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies.Autoimmunity to desmocollin 3 in pemphigus vulgaris.Signaling dependent and independent mechanisms in pemphigus vulgaris blister formationPemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin.Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management.Current and prospective understanding of clinical classification, pathomechanisms and therapy in pemphigus.Number II. Pemphigus vulgaris.Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin.Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris.Desmoglein autoimmunity in the pathogenesis of pemphigus.The desmosome and pemphigus.A perspective of pemphigus from bedside and laboratory-bench.Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies.Intercellular junction assembly, dynamics, and homeostasis.Cell-cell connectivity: desmosomes and disease.Structural and functional diversity of desmosomes.Desmosomal cadherins and signaling: lessons from autoimmune disease.Desmosomes and extradesmosomal adhesive signaling contacts in pemphigus.150(th) anniversary series: Desmosomes and autoimmune disease, perspective of dynamic desmosome remodeling and its impairments in pemphigus.Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis.E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion.Bullous pemphigoid IgG induces BP180 internalization via a macropinocytic pathway.Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3Efficacy of intravenous immunoglobulin (IVIG) affinity-purified anti-desmoglein anti-idiotypic antibodies in the treatment of an experimental model of pemphigus vulgaris.Low to high Ca2+ -switch causes phosphorylation and association of desmocollin 3 with plakoglobin and desmoglein 3 in cultured keratinocytes.Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity.Pathogenic monoclonal antibody against desmoglein 3 augments desmoglein 3 and p38 MAPK phosphorylation in human squamous carcinoma cell line.Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies.Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens.Rituximab in pemphigus.Plakoglobin-dependent disruption of the desmosomal plaque in pemphigus vulgaris.
P2860
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P2860
Assembly pathway of desmoglein 3 to desmosomes and its perturbation by pemphigus vulgaris-IgG in cultured keratinocytes, as revealed by time-lapsed labeling immunoelectron microscopy.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Assembly pathway of desmoglein ...... ing immunoelectron microscopy.
@en
type
label
Assembly pathway of desmoglein ...... ing immunoelectron microscopy.
@en
prefLabel
Assembly pathway of desmoglein ...... ing immunoelectron microscopy.
@en
P2093
P2860
P1476
Assembly pathway of desmoglein ...... ing immunoelectron microscopy.
@en
P2093
P2860
P2888
P304
P356
10.1038/LABINVEST.3780168
P577
2000-10-01T00:00:00Z