A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. - Wikidata - wikimedia - TriplyDB

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.

http://www.wikidata.org/entity/Q40867583

about

Genetic and epigenetic regulation of intestinal fibrosis Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis Epigenetics in lung fibrosis: from pathobiology to treatment perspective.The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2 Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1 Oxidative Stress, Nrf2, and Epigenetic Modification Contribute to Anticancer Drug Resistance.Epigenetic targets for novel therapies of lung diseases.H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis.Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression.DNA methylation regulated gene expression in organ fibrosis.Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation.Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor β-1 Activation Mechanism.A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.Interplay Between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis.Fibrosis: Lessons from OMICS analyses of the human lung.Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells.ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis.Histone modifications and their role in epigenetics of atopy and allergic diseases.Epigenetic Regulation of Myofibroblast Phenotypes in Fibrosis IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE

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P2860

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.

http://www.wikidata.org/entity/Q40867583

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

@wuu

2014年论文

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2014年论文

@zh-cn

name

A central role for G9a and EZH ...... idiopathic pulmonary fibrosis.

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type

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A central role for G9a and EZH ...... idiopathic pulmonary fibrosis.

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prefLabel

A central role for G9a and EZH ...... idiopathic pulmonary fibrosis.

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A central role for G9a and EZH ...... idiopathic pulmonary fibrosis.

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Carol A Feghali-Bostwick

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Linhua Pang

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William R Coward

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P2860

The Polycomb group protein EZH2 directly controls DNA methylation

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

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3183-3196

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10.1096/FJ.13-241760

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pulmonary fibrosis

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