Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
about
Oncolytic adenovirus-mediated therapy for prostate cancerA mammalianized synthetic nitroreductase gene for high-level expressionBiological approaches to therapy of pancreatic cancer.Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives.Gene therapy in pancreatic cancer.Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracilE. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954Specifically targeted gene therapy for small-cell lung cancer.Targeted prodrug approaches for hormone refractory prostate cancer.Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo.A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984].Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.Vectors based on reducible polycations facilitate intracellular release of nucleic acids.Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
P2860
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P2860
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Sensitisation of human carcino ...... ion of E. coli nitroreductase.
@en
type
label
Sensitisation of human carcino ...... ion of E. coli nitroreductase.
@en
prefLabel
Sensitisation of human carcino ...... ion of E. coli nitroreductase.
@en
P2093
P2860
P1476
Sensitisation of human carcino ...... sion of E. coli nitroreductase
@en
P2093
A Mountain
C J Wrighton
M G Gilligan
P F Searle
S J Weedon
P2860
P304
P356
10.1002/(SICI)1097-0215(20000615)86:6<848::AID-IJC14>3.0.CO;2-B
P577
2000-06-01T00:00:00Z