Ionizing radiation activates the ATM kinase throughout the cell cycle. - Wikidata - wikimedia - TriplyDB

Ionizing radiation activates the ATM kinase throughout the cell cycle.

Ionizing radiation activates the ATM kinase throughout the cell cycle.

http://www.wikidata.org/entity/Q40893193

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy Involvement of human MOF in ATM function Inhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection.Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.The effect of acute dose charge particle radiation on expression of DNA repair genes in mice.Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.A plausible model for the digital response of p53 to DNA damage.γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster ATM-NF-kappaB connection as a target for tumor radiosensitization Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.ATM function and telomere stability.Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.Identification and analysis of a hyperactive mutant form of Drosophila P-element transposase.DNA damage and autophagy.Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer ATM and ATR: sensing DNA damage.(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.Chromatin modifications and the DNA damage response to ionizing radiation.Candidate protein biodosimeters of human exposure to ionizing radiation.RIF1 counteracts BRCA1-mediated end resection during DNA repair The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations.NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.Stress response of a p53 homologue in the radioresistant Sf9 insect cells.Detecting ATM-dependent chromatin modification in DNA damage response.Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.A multifaceted role for MOF histone modifying factor in genome maintenance.MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.Low and high linear energy transfer radiation sensitization of HCC cells by metformin.DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

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Ionizing radiation activates the ATM kinase throughout the cell cycle.

http://www.wikidata.org/entity/Q40893193

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2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年學術文章

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2000年學術文章

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2000年學術文章

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Ionizing radiation activates the ATM kinase throughout the cell cycle.

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Ionizing radiation activates the ATM kinase throughout the cell cycle.

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Ionizing radiation activates the ATM kinase throughout the cell cycle.

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Ionizing radiation activates the ATM kinase throughout the cell cycle.

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Dhar S

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Kastan MB

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Lieberman HB

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Pandita TK

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Taya Y

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Zheng W

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P2860

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

Enhanced phosphorylation of p53 by ATM in response to DNA damage

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Cell cycle control and cancer

ATM associates with and phosphorylates p53: mapping the region of interaction.

Atm inactivation results in aberrant telomere clustering during meiotic prophase.

Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment

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10.1038/SJ.ONC.1203444

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