Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.
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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalingThe WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsI-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.The Axin1 scaffold protein promotes formation of a degradation complex for c-MycAxin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityThe links between axin and carcinogenesisApc mutation enhances PyMT-induced mammary tumorigenesisA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinaseAxin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activationCasein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathwaysThe DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanismsBoth the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesisGeneration of Axin1 conditional mutant miceInhibition of Wnt signaling pathway by a novel axin-binding proteinAxin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formationAxin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functionsProtein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signalingMechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionWnt signalling pathway parameters for mammalian cellsDifferential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formationPLK1 interacts and phosphorylates Axin that is essential for proper centrosome formation.Intrinsic disorder in scaffold proteins: getting more from lessMDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Impaired neural development caused by inducible expression of Axin in transgenic mice.Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes.Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice.Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways.Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.The various roles of ubiquitin in Wnt pathway regulation.Diversity of axin in signaling pathways and its relation to colorectal cancer.c-Jun, at the crossroad of the signaling network.AXIN1 and AXIN2 variants in gastrointestinal cancers.Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways.AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathwayRelationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer.Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.JNK-dependent AP-1 activation is required for aristolochic acid-induced TGF-β1 synthesis in human renal proximal epithelial cells.
P2860
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P2860
Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Axin forms a complex with MEKK ...... s distinct from Wnt signaling.
@en
type
label
Axin forms a complex with MEKK ...... s distinct from Wnt signaling.
@en
prefLabel
Axin forms a complex with MEKK ...... s distinct from Wnt signaling.
@en
P2093
P2860
P356
P1476
Axin forms a complex with MEKK ...... s distinct from Wnt signaling.
@en
P2093
P2860
P304
35247-35254
P356
10.1074/JBC.274.49.35247
P407
P577
1999-12-01T00:00:00Z