Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.
about
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinaseMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsStructural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerA novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapyAutoimmunity in primary T-cell immunodeficiencies.p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.SH2 domains: modulators of nonreceptor tyrosine kinase activity.ZAP-70: an essential kinase in T-cell signalingNovel Mutation of ZAP-70-related Combined Immunodeficiency: First Case from the National Iranian Registry and Review of the Literature.The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system.A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder.Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily.Cellular and viral Fos proteins are degraded by different proteolytic systems.A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.Hsp90 Recognizes a Common Surface on Client Kinases
P2860
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P2860
Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Temperature-sensitive ZAP70 mu ...... kinase domain mutant by Cdc37.
@en
type
label
Temperature-sensitive ZAP70 mu ...... kinase domain mutant by Cdc37.
@en
prefLabel
Temperature-sensitive ZAP70 mu ...... kinase domain mutant by Cdc37.
@en
P2093
P2860
P356
P1476
Temperature-sensitive ZAP70 mu ...... kinase domain mutant by Cdc37.
@en
P2093
Katamura K
Suzuki-Fujimoto T
P2860
P304
34515-34518
P356
10.1074/JBC.274.49.34515
P407
P577
1999-12-01T00:00:00Z