Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase.
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Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activitiesPhosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factorBeta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2Role of tyrosine kinase activity in alpha-adrenergic inhibition of the beta-adrenergically regulated L-type Ca(2+) current in guinea-pig ventricular myocytesActivation of tyrosine kinase of EGFR induces Gbetagamma-dependent GRK-EGFR complex formation.pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation.Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.Identification of phosphoproteins associated with human neutrophil granules following chemotactic peptide stimulation.Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: a novel mechanism for modulating cell signalingG protein-coupled receptor kinases: more than just kinases and not only for GPCRsAKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes.Cross-regulation of VPAC2 receptor internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2.Molecular Pharmacology of δ-Opioid Receptors.G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation.Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulationPositive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression.The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease.The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targetsG Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization.Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization.Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells.Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling.EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysisSrc phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.MAPK-dependent degradation of G protein-coupled receptor kinase 2.Heterologous inhibition of G protein-coupled receptor endocytosis mediated by receptor-specific trafficking of beta-arrestins.Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targetingRoles of c-Src in alpha1B-adrenoceptor phosphorylation and desensitization.The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.Involvement of the C-terminal proline-rich motif of G protein-coupled receptor kinases in recognition of activated rhodopsin.Not so strange bedfellows: G-protein-coupled receptors and Src family kinases.Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes.Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.Mobility of acetylcholine receptors in command Helix lucorum neurons in a cellular analog of habituation.
P2860
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P2860
Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Agonist-dependent phosphorylat ...... (GRK2) by Src tyrosine kinase.
@en
type
label
Agonist-dependent phosphorylat ...... (GRK2) by Src tyrosine kinase.
@en
prefLabel
Agonist-dependent phosphorylat ...... (GRK2) by Src tyrosine kinase.
@en
P2093
P2860
P356
P1476
Agonist-dependent phosphorylat ...... (GRK2) by Src tyrosine kinase.
@en
P2093
P2860
P304
34411-34416
P356
10.1074/JBC.274.48.34411
P407
P577
1999-11-01T00:00:00Z