Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
about
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNSBiosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profilingGSK-3β: A Bifunctional Role in Cell Death Pathways12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3Antimicrobial, antimycobacterial and antibiofilm properties of Couroupita guianensis Aubl. fruit extractMultiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5.Indirubin and Indirubin Derivatives for Counteracting Proliferative DiseasesAre the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?Biotechnological applications of functional metagenomics in the food and pharmaceutical industriesTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsDiscovery of new anticancer agents from higher plantsAn indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivinCell migration in paediatric glioma; characterisation and potential therapeutic targeting.Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor siteStructural insight into the altered substrate specificity of human cytochrome P450 2A6 mutantsActivation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologueIndirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urineInhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cellsSynthesis of a dual functional anti-MDR tumor agent PH II-7 with elucidations of anti-tumor effects and mechanismsCharacterization of a novel phenol hydroxylase in indoles biotransformation from a strain Arthrobacter sp. W1 [corrected]Protein kinases--the major drug targets of the twenty-first century?The specificities of protein kinase inhibitors: an updateChemical modulation of memory formation in larval zebrafish.p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Cytochrome P450 enzymes in the generation of commercial products.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Role of STAT3 in cancer metastasis and translational advances.In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication.Enterohemorrhagic Escherichia coli biofilms are inhibited by 7-hydroxyindole and stimulated by isatin.Indirubin Increases CD4+CD25+Foxp3+ Regulatory T Cells to Prevent Immune Thrombocytopenia in Mice.Cancer and virus leads by HTS, chemical design and SEA data miningInhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien LiquidCharacterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells.An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3Iodine/palladium approaches to the synthesis of polyheterocyclic compounds.Anti-Inflammatory Activity and Structure-Activity Relationships of Brominated Indoles from a Marine Mollusc.Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1.A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention.
P2860
Q21129334-E9A90713-AD35-4502-84B9-D5AA753669C4Q21266662-41BF2F5F-FF88-4677-9D20-49B441C508B8Q21285144-908E94B7-A47E-4CA8-88E2-FFE1C1143EA8Q24631554-CE849562-47E3-49A5-B052-10A2821B5A7AQ24633975-ED3E381A-5FE9-4181-A729-9820A0243899Q24814111-EAE3B857-8E06-45F2-B2E1-4A1684ACDBC5Q26784341-305F9A36-49A2-43D7-977D-2481A67E40A5Q26795884-1F78BB31-C885-4544-A979-9E21D1829ACBQ26801646-911B6492-0B39-49A2-8951-EB88355C579EQ26827580-58557150-8E08-4F9D-A3B8-263254EF0E12Q27006814-6379F1C3-57E9-4818-8874-CFB91D8C854EQ27310385-6CAE3E22-A55B-424E-A3BA-06E40C6AB989Q27332147-37CC21BE-34B0-4B03-BDB0-7609946DBF20Q27625712-3E813644-3FE9-46A4-A08D-53992845F989Q27645089-7D1D0441-D83E-45FF-9A18-986282CE1A5BQ27976463-34F0BAC6-EEB6-4F74-A38F-C8066BD14C31Q28203680-37380E62-F9D0-42CF-B010-BA34235FDFFFQ28346772-092AD04E-58ED-43F2-88D6-7AAA00365610Q28481389-0D3788F6-1270-4432-835C-B3DE3B342E36Q28483757-3DA9A97A-2F17-47CC-882D-68EB9440F0CDQ29615339-8C3B5EC5-6737-4878-B1A8-84494B583916Q30014834-2D134BE7-DD63-44E5-A32F-55D85DE4C47DQ30474076-B74C1B43-D31D-4462-A1CB-817A84BA881AQ30847612-091C5D17-EAD4-4144-8906-C11C3111B816Q31096798-9A167CAE-41E1-4343-8A80-123BBB219B69Q31098941-94B96FD6-751B-463A-82E9-1FFC0094709DQ31142794-742B84C5-67A0-434D-881D-BCFC6B4E1649Q33237247-777A90AE-C31D-4CF6-8DD6-41ADA9CB5F30Q33268403-9AFEBD3D-6567-4CAD-9FAB-F2BAC999E1FEQ33283839-99A45CE0-F124-4943-8DC3-071A7E25F7EDQ33427555-2E9B15F2-7461-4C06-8091-FED5EDBC7613Q33508912-273D9FC9-1291-4499-9583-3200FD1A53F9Q33568201-C6518608-A636-4809-A6F9-4C17EA2A9201Q33611307-9B1766AF-17AE-4CC7-87E5-75D0D4D1FEBBQ33688195-B1E577AA-49C6-471E-9B0F-6A002DBB5616Q33703501-366E506D-8EEC-4CDF-A9BF-CC30EF5E1086Q33744128-3248BD68-CB95-4EE3-BD28-DE80D24BCF05Q33770989-74D2938A-61DF-457F-844F-616F783CDC70Q33829852-4C6E9532-DEEA-41BB-BBCD-C47EF84F9110Q33968462-A9F87BE5-E4C1-4E5C-BB06-987061C33E45
P2860
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Indirubin, the active constitu ...... bits cyclin-dependent kinases.
@en
type
label
Indirubin, the active constitu ...... bits cyclin-dependent kinases.
@en
prefLabel
Indirubin, the active constitu ...... bits cyclin-dependent kinases.
@en
P2093
P2860
P356
P1433
P1476
Indirubin, the active constitu ...... bits cyclin-dependent kinases.
@en
P2093
Eisenbrand G
Endicott JA
P2860
P2888
P356
10.1038/9035
P577
1999-05-01T00:00:00Z