MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells.
about
Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformationRAS oncogenes: weaving a tumorigenic webEpidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysMAPK signaling pathway regulates p27 phosphorylation at threonin 187 as part of the mechanism triggered by early-weaning to induce cell proliferation in rat gastric mucosa.ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cellsTudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation.Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targetsHigh ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patientsCancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodelingProliferation of intestinal crypt cells by gastrin-induced ornithine decarboxylaseArrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.MAP kinase dependent cyclinE/cdk2 activity promotes DNA replication in early sea urchin embryos.Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1).SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers.That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiationStreptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors.A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors.The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells.Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition.Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation.
P2860
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P2860
MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
MAP kinase cascade is required ...... roblasts and epithelial cells.
@en
type
label
MAP kinase cascade is required ...... roblasts and epithelial cells.
@en
prefLabel
MAP kinase cascade is required ...... roblasts and epithelial cells.
@en
P2093
P2860
P1476
MAP kinase cascade is required ...... roblasts and epithelial cells.
@en
P2093
Boucher MJ
L'Allemain G
P2860
P304
P356
10.1152/AJPCELL.1999.277.4.C652
P407
P433
P577
1999-10-01T00:00:00Z