NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis.
about
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyModulation of Akt kinase activity by binding to Hsp90BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell deathExtracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injurySolution structure of a Bcl-2 homolog from Kaposi sarcoma virus.Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactionsRecent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xLBcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motifDownregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis.Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatmentRemoval of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.BH4 domain of Bcl-2 as a novel target for cancer therapyThe C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cellsCharacterization of MUDENG, a novel anti-apoptotic protein.BCL-2 family of proteins and mammary cellular fate.Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosisEmerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Bcl-2 proteins and calcium signaling: complexity beneath the surface.Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity.Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity.BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo.Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis.LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway.Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Evidence for crucial electrostatic interactions between Bcl-2 homology domains BH3 and BH4 in the anti-apoptotic Nr-13 protein.Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells.Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells.Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination.A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function.Alpha 5/6 helix domains together with N-terminus determine the apoptotic potency of the Bcl-2 family proteins.
P2860
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P2860
NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
NH2-terminal BH4 domain of Bcl ...... x and inhibition of apoptosis.
@en
type
label
NH2-terminal BH4 domain of Bcl ...... x and inhibition of apoptosis.
@en
prefLabel
NH2-terminal BH4 domain of Bcl ...... x and inhibition of apoptosis.
@en
P2093
P2860
P356
P1476
NH2-terminal BH4 domain of Bcl ...... x and inhibition of apoptosis.
@en
P2093
P2860
P304
20415-20420
P356
10.1074/JBC.274.29.20415
P407
P577
1999-07-01T00:00:00Z