Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.
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P1343
When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulinPhosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cellsMitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptideCo-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesisRanGAP1 induces GTPase activity of nuclear Ras-related RanThe Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motifMolecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cellsSeparate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processingA protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2pRestoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding proteinbeta-catenin can be transported into the nucleus in a Ran-unassisted mannerInhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorChromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientationCortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphaseRan GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assemblyTD-60 is required for interphase cell cycle progressionSamp1, a RanGTP binding transmembrane protein in the inner nuclear membrane.Ran GTPase regulates Mad2 localization to the nuclear pore complex.Nuclear PRP20 protein is required for mRNA exportSmall nucleolar RNAs encoded by introns of the human cell cycle regulatory gene RCC1.Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.RCC1 and nuclear organization.A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutantHighly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cellsMethylation-silencing RCC1 expression is associated with tumorigenesis and depth of invasion in gastric cancer.RanBP2 associates with Ubc9p and a modified form of RanGAP1RanGTP aids anaphase entry through Ubr5-mediated protein turnover.A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo.NuMA is required for the proper completion of mitosis.Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210RCC1, a regulator of mitosis, is essential for DNA replication2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells.The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.
P2860
Q22008010-9C8DD68B-0127-4696-9E74-D1DC177C64BEQ24316034-056B9EF5-6871-4084-BC1F-CBA41F7D236BQ24316110-0E97C7AE-5D5C-412A-808D-9AC555EB4F65Q24316332-728B070C-AD52-4FD5-BED6-E7B4EC5019DFQ24319927-7D97F227-14A4-4579-9BCE-551B4841F6E4Q24564044-28CEDD76-1ED5-4D15-A574-9CFC44864A64Q24564692-729A3F4F-6854-4377-BCDE-581920DDFE41Q24629674-FD39D5A4-DCE1-4B3C-9ACC-09B2070D9D70Q24652656-2739CA87-3AAB-4B17-92D1-4DFBDDC8E519Q27931572-878F4B55-8A92-4D41-80B5-EB5933BDE13BQ27936269-6DFA1B19-8356-4C89-BDEE-A24BD383764EQ27936663-AE223B25-BFEB-4555-AB76-B61784062182Q28588927-B11609A6-F7B2-4512-A69A-674F48222F53Q28640339-54C06958-529A-494D-99B6-78EF5FDB4833Q29620193-59002721-A315-4731-BC38-893B4C902796Q29871463-F578FE2A-987C-4FA2-BE38-448F4BCE3A5AQ29871470-2B0C61A0-E7AA-466E-8575-402D536B130BQ30476914-A00FE1A6-8DCA-40AE-896E-BC97F1D7FA57Q30499284-FA1E97BB-BFD3-452A-A9C5-59848208730DQ30538144-8A39EA6E-27C2-4210-9F4C-2F09915D5BB6Q31814825-1A2CC591-C51B-408D-B80D-9F97250AD592Q33859911-54E5EA52-D85D-4FCD-AABA-2F6F9B4106F3Q34041464-ADD39EB4-B4E0-4DDE-9D6A-4ABAF62DBEB1Q34055897-C3728905-F27D-4060-AA8C-D38E0477233BQ34056045-031C68AB-9195-4ACC-AF07-01E0EB490146Q34430190-C2A81EB2-6153-40A3-AA82-C84FD4A97AEEQ34431295-B8CC3E06-4D20-4DFF-8193-2FBFB0B78E8FQ34671494-A5B78C10-6B7A-448E-B6DF-85E3FB6518D4Q34742786-5BED72EC-7BDA-4FEE-9B88-F46A28ED62EBQ35537879-55F7AFDE-4DAB-43AE-BC81-047507BB06ABQ35834690-5EBDD9D5-B154-40F6-8D2F-5A1A330D138CQ35908091-5621D975-7069-49B9-91A1-70328287B38FQ36105014-34678677-1812-450C-8F68-24EF6DBC85F4Q36149393-88C810CD-25F6-4756-AF3C-23358F660CD8Q36324250-E3EEDF15-782F-45F2-9B0D-19E14AB7DD6EQ36383071-A7D843EF-716E-4669-AF53-35CDCD20A3F2Q36531419-582B7753-57C5-4C23-A5C3-BEA7CCD330D8Q36820731-5F0DDC83-DD39-496C-80C2-3988491C2969Q36892253-50E2349A-10D5-462C-8A6B-D6362CBCB2C2Q37052271-F6A5A483-C06C-401B-A995-BBC45D100E88
P2860
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Loss of RCC1, a nuclear DNA-bi ...... c2 protein kinase and mitosis.
@en
type
label
Loss of RCC1, a nuclear DNA-bi ...... c2 protein kinase and mitosis.
@en
prefLabel
Loss of RCC1, a nuclear DNA-bi ...... c2 protein kinase and mitosis.
@en
P2093
P2860
P1433
P1476
Loss of RCC1, a nuclear DNA-bi ...... dc2 protein kinase and mitosis
@en
P2093
Nishimoto T
Nishitani H
Yamashita K
P2860
P304
P356
10.1002/J.1460-2075.1991.TB07675.X
P407
P4510
P577
1991-06-01T00:00:00Z