Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B. Evidence that directed migration does not require rapid modulation of signaling at the receptor level.
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Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNTPivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxisCCR2 acts as scavenger for CCL2 during monocyte chemotaxisModeling cell gradient sensing and migration in competing chemoattractant fieldsMultimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxisThe C-terminal domain LLKIL motif of CXCR2 is required for ligand-mediated polarization of early signals during chemotaxisThe IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells.Direct binding of a fragment of the Wiskott-Aldrich syndrome protein to the C-terminal end of the anaphylatoxin C5a receptor.Chemokine receptor trafficking and viral replication.Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.Chemokine receptor internalization and intracellular trafficking.Identification of C-C chemokine receptor 1 (CCR1) as the monocyte hemofiltrate C-C chemokine (HCC)-1 receptorReceptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or GsChemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by betagamma dimers released by activation of Galphai-coupled receptors.Modeling the role of homologous receptor desensitization in cell gradient sensingUnique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion.Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.How to understand and outwit adaptationOn the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.Galpha protein selectivity determinant specified by a viral chemokine receptor-conserved region in the C tail of the human herpesvirus 8 g protein-coupled receptor.The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration.Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation.Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis.Multiple signaling pathways of human interleukin-8 receptor A. Independent regulation by phosphorylation.Analysis of the pharmacokinetic/pharmacodynamic relationship of a small molecule CXCR3 antagonist, NBI-74330, using a murine CXCR3 internalization assay.A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activatioA membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5.A module for Rac temporal signal integration revealed with optogenetics.G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions.Targeting the leukocyte activation cascade: getting to the site of inflammation using microfabricated assays.Modeling emergent tissue organization involving high-speed migrating cells in a flow equilibrium.Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes.
P2860
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P2860
Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B. Evidence that directed migration does not require rapid modulation of signaling at the receptor level.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Dissociation of chemotaxis fro ...... gnaling at the receptor level.
@en
type
label
Dissociation of chemotaxis fro ...... gnaling at the receptor level.
@en
prefLabel
Dissociation of chemotaxis fro ...... gnaling at the receptor level.
@en
P2093
P2860
P356
P1476
Dissociation of chemotaxis fro ...... gnaling at the receptor level.
@en
P2093
P2860
P304
25037-25042
P356
10.1074/JBC.272.40.25037
P407
P577
1997-10-01T00:00:00Z