The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow
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Adhesion molecules in CNS disorders: biomarker and therapeutic targetsStructural basis of integrin regulation and signalingComparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters.Leukocyte adhesion molecules in animal models of inflammatory bowel diseasePSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.I-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow.An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateImportance of force linkage in mechanochemistry of adhesion receptors.The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas.Neutrophil arrest by LFA-1 activationStrategies for cell membrane functionalization.A mechanism for antibody-mediated outside-in activation of LFA-1.Avidity modulation activates adhesion under flow and requires cooperativity among adhesion receptors.High-temporal-resolution analysis demonstrates that ICAM-1 stabilizes WEHI 274.1 monocytic cell rolling on endothelium.Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium.Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.
P2860
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P2860
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The lymphocyte function-associ ...... nd ICAM-3 in hydrodynamic flow
@en
type
label
The lymphocyte function-associ ...... nd ICAM-3 in hydrodynamic flow
@en
prefLabel
The lymphocyte function-associ ...... nd ICAM-3 in hydrodynamic flow
@en
P2860
P356
P1476
The lymphocyte function-associ ...... nd ICAM-3 in hydrodynamic flow
@en
P2093
P2860
P304
P356
10.1084/JEM.186.5.719
P407
P577
1997-08-01T00:00:00Z