A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)
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Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain functionStructures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studiesEfalizumab binding to the LFA-1 L I domain blocks ICAM-1 binding via steric hindranceAn Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in CollagensThe von willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motifCrystal structure of the I domain from integrin alpha2beta1A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1The role of alpha and beta chains in ligand recognition by beta 7 integrinsAssociation of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive stateIntegrative analysis of T cell motility from multi-channel microscopy data using TIAM.Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptidesAmino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).FRET based quantification and screening technology platform for the interactions of leukocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1).Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.Force spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.ICAM-1 mediates surface contact between neutrophils and keratocytes following corneal epithelial abrasion in the mouse.An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.Insights into integrin-ligand binding and activation from the first crystal structure.Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsTransmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain.Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface.Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit.Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxinDimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesionTwo functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures.Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.Cell adhesion in vascular biology. New insights into integrin-ligand interaction.Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas.The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activationADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells.Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor.Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1.Identification of the binding site in intercellular adhesion molecule 1 for its receptor, leukocyte function-associated antigen 1.Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding.
P2860
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P2860
A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@ast
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@en
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@nl
type
label
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@ast
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@en
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@nl
prefLabel
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@ast
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@en
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@nl
P2860
P356
P1476
A binding interface on the I d ...... r adhesion molecule 1 (ICAM-1)
@en
P2093
P2860
P304
P356
10.1074/JBC.270.32.19008
P407
P577
1995-08-11T00:00:00Z