Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.
about
An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domainStructures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.The role of alpha and beta chains in ligand recognition by beta 7 integrinsComputation of conformational coupling in allosteric proteinsForce spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesionStructural modifications of ICAM-1 cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cellsNMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.Dual function for a unique site within the beta2I domain of integrin alphaMbeta2.Integrin beta1-chain residues involved in substrate recognition and specificity of binding to invasin.NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domainModel of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity.Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.Generation of a minimal alpha5beta1 integrin-Fc fragment.Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium.Structural and ICAM-1-Docking Properties of a Cyclic Peptide from the I-domain of LFA-1: An inhibitor of ICAM-1/LFA-1-mediated T-cell adhesionMolecular Basis of Ligand Recognition by Integrin α5β1
P2860
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P2860
Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Mapping the intercellular adhe ...... function-associated antigen-1.
@en
Mapping the intercellular adhe ...... function-associated antigen-1.
@nl
type
label
Mapping the intercellular adhe ...... function-associated antigen-1.
@en
Mapping the intercellular adhe ...... function-associated antigen-1.
@nl
prefLabel
Mapping the intercellular adhe ...... function-associated antigen-1.
@en
Mapping the intercellular adhe ...... function-associated antigen-1.
@nl
P2093
P2860
P356
P1476
Mapping the intercellular adhe ...... function-associated antigen-1.
@en
P2093
P2860
P304
28937-28944
P356
10.1074/JBC.273.44.28937
P407
P577
1998-10-01T00:00:00Z