Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
about
The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factorSubstitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingPresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauSignal transduction by the Wnt family of ligandsdelta-catenin, an adhesive junction-associated protein which promotes cell scatteringDirect interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interactionLocalization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cellsXarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region.Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.C-Src-mediated phosphorylation of δ-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin.Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo.A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease.δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.Presenilins: members of the gamma-secretase quartets, but part-time soloists too.Discovering the molecular components of intercellular junctions--a historical view.Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease.δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.Twenty Years of Presenilins--Important Proteins in Health and Disease.Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasisPresenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant.The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.CTNND2-a candidate gene for reading problems and mild intellectual disability.Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation.Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels.A partnership that delivers.Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques.Presenilins and the intramembrane proteolysis of proteins: facts and fiction.p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction
P2860
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P2860
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
@en
type
label
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
@en
prefLabel
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
@en
P2093
P1433
P1476
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
@en
P2093
P304
P356
10.1097/00001756-199704140-00033
P577
1997-04-01T00:00:00Z