Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
about
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's diseaseCharacterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas.Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space.Secretases as targets for drug design in Alzheimer's disease.Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.The ins and outs of presenilin 1 membrane topology.The presenilins turned inside out: implications for their structures and functions.Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologicallyGenetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Presenilin function and gamma-secretase activity.The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movementAlzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistributionCytoprotection against mechanical forces delivered through beta 1 integrins requires induction of filamin A.The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2.Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neuronsPresenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
P2860
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P2860
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@ast
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@en
type
label
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@ast
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@en
prefLabel
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@ast
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@en
P2093
P2860
P356
P1476
Endogenous presenilin 1 redist ...... at cells to a collagen matrix.
@en
P2093
A Dranovsky
A L Schwarzman
D Goldgaber
P H St George-Hyslop
P2860
P304
P356
10.1073/PNAS.96.14.7932
P407
P577
1999-07-01T00:00:00Z