Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.
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Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisA reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αHigh-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activationA role for Src in signal relay by the platelet-derived growth factor alpha receptorOver-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathwaySynergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase.A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells.Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cellsKris DeMali: fixed on cell adhesion. Interview by Ruth Williams.Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoformImatinib mesylate for the treatment of pulmonary arterial hypertension.Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis.Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts.Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways.Regulation of phospholipase C-gamma activity by glycosphingolipids.Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.Bovine papillomavirus E5 protein induces the formation of signal transduction complexes containing dimeric activated platelet-derived growth factor beta receptor and associated signaling proteins.Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis.Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways.Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation.Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation.Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals.A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.A human brain tumor-derived PDGFR-alpha deletion mutant is transforming.
P2860
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P2860
Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Platelet-derived growth factor ...... phosphatidylinositol 3 kinase.
@en
type
label
Platelet-derived growth factor ...... phosphatidylinositol 3 kinase.
@en
prefLabel
Platelet-derived growth factor ...... phosphatidylinositol 3 kinase.
@en
P2093
P2860
P356
P1476
Platelet-derived growth factor ...... phosphatidylinositol 3 kinase.
@en
P2093
Kazlauskas A
Whiteford CC
P2860
P304
P356
10.1074/JBC.272.14.9011
P407
P577
1997-04-01T00:00:00Z