Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.
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Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysisLovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductaseDer3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complexCholesterol promotes hemifusion and pore widening in membrane fusion induced by influenza hemagglutinin.Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity.Endoplasmic reticulum quality control of oligomeric membrane proteins: topogenic determinants involved in the degradation of the unassembled Na,K-ATPase alpha subunit and in its stabilization by beta subunit assembly.Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade.Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fatePurification and Recognition of Recombinant Mouse P2X(1) Receptors Expressed in a Baculovirus System.Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast.Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes.Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase.Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane proteaseDegradation of hepatic stearyl CoA delta 9-desaturase.Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipidsA novel quality control compartment derived from the endoplasmic reticulumUbiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation.Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1.The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Role of ubiquitin in proteasomal degradation of mutant alpha(1)-antitrypsin Z in the endoplasmic reticulum.Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells.Stabilization of mutant 46-kDa mannose 6-phosphate receptors by proteasomal inhibitor lactacystin.gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein.Proparathyroid hormone-related protein is associated with the chaperone protein BiP and undergoes proteasome-mediated degradation.Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase.Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase.Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathway.Tetramerization domain of human butyrylcholinesterase is at the C-terminus.Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation.Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease.Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase.Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.
P2860
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P2860
Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Degradation of 3-hydroxy-3-met ...... susceptibility to proteolysis.
@en
type
label
Degradation of 3-hydroxy-3-met ...... susceptibility to proteolysis.
@en
prefLabel
Degradation of 3-hydroxy-3-met ...... susceptibility to proteolysis.
@en
P2093
P2860
P356
P1476
Degradation of 3-hydroxy-3-met ...... susceptibility to proteolysis
@en
P2093
P2860
P304
25630-25638
P356
10.1074/JBC.271.41.25630
P407
P50
P577
1996-10-01T00:00:00Z