Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.
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Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complexOverexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsApolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisTunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cellsMechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteinsEpigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDLImpaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoproteinArylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cellsMicrosomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidationApolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.The role of the LDL receptor in apolipoprotein B secretion.Apolipoprotein B-containing lipoprotein assembly in microsomal triglyceride transfer protein-deficient McA-RH7777 cells.Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins.Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substratesMicrosomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)The many intersecting pathways underlying apolipoprotein B secretion and degradationThe ever-expanding role of degradation in the regulation of apolipoprotein B metabolism.ESCRT regulates surface expression of the Kir2.1 potassium channel.Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production.Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly.Insights from human congenital disorders of intestinal lipid metabolism.Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.Charged amino acid residues 997-1000 of human apolipoprotein B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cellsThe AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway.Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly.Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells.Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes.Amino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein BApolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER.Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis.Apolipoprotein B, a paradigm for proteins regulated by intracellular degradation, does not undergo intracellular degradation in CaCo2 cells.Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription.
P2860
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P2860
Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Apoprotein B100 has a prolonge ...... nsfer protein to independence.
@en
type
label
Apoprotein B100 has a prolonge ...... nsfer protein to independence.
@en
prefLabel
Apoprotein B100 has a prolonge ...... nsfer protein to independence.
@en
P2093
P2860
P356
P1476
Apoprotein B100 has a prolonge ...... ansfer protein to independence
@en
P2093
D M Mitchell
H N Ginsberg
J D Aitchison
R Pariyarath
P2860
P304
14733-14738
P356
10.1073/PNAS.95.25.14733
P407
P577
1998-12-01T00:00:00Z