The merlin tumor suppressor localizes preferentially in membrane ruffles.
about
Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteinsStructural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization.Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalThe neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral associationConditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumorsMolecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsMolecular analysis of the NF2 tumor-suppressor gene in schwannomatosisFunctional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutationsNHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane.Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencingModeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.Three determinants in ezrin are responsible for cell extension activity.Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-LMolecular insights into NF2/Merlin tumor suppressor function.The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells.Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activityUniversal absence of merlin, but not other ERM family members, in schwannomas.β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.
P2860
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P2860
The merlin tumor suppressor localizes preferentially in membrane ruffles.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The merlin tumor suppressor localizes preferentially in membrane ruffles.
@en
type
label
The merlin tumor suppressor localizes preferentially in membrane ruffles.
@en
prefLabel
The merlin tumor suppressor localizes preferentially in membrane ruffles.
@en
P2093
P1433
P1476
The merlin tumor suppressor localizes preferentially in membrane ruffles.
@en
P2093
Beauchamp R
Gonzalez-Agosti C
P304
P407
P577
1996-09-01T00:00:00Z