Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing
about
Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin.Cadherin signaling: keeping cells in touchNeurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering studyMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalDevelopment of drug treatments for neurofibromatosis type 2-associated vestibular schwannoma.Merlin/ERM proteins establish cortical asymmetry and centrosome position.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastomaMerlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesisMicrotubule-mediated transport of the tumor-suppressor protein Merlin and its mutants.The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2-dependent manner.Differential NF2 Gene Status in Sporadic Vestibular Schwannomas and its Prognostic Impact on Tumour Growth PatternsNf2/Merlin controls progenitor homeostasis and tumorigenesis in the liverThe tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAFMerlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signalingAberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma.Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth.Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesisMerlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation.Spatial regulation of receptor tyrosine kinases in development and cancer.Merlin: the wizard requires protein stability to function as a tumor suppressor.The N-cadherin cytoplasmic domain confers anchorage-independent growth and the loss of contact inhibition.A molecular mechanotransduction pathway regulates collective migration of epithelial cells.Functional interdependence of NHE1 and merlin in human melanoma cells.Schwannomas exhibit distinct size-dependent gene-expression patterns.Merlin sumoylation is required for its tumor suppressor activity.The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton.Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma.Merlin in organ size control and tumorigenesis: Hippo versus EGFR?Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.
P2860
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P2860
Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Localization to the cortical c ...... owth factor receptor silencing
@ast
Localization to the cortical c ...... owth factor receptor silencing
@en
type
label
Localization to the cortical c ...... owth factor receptor silencing
@ast
Localization to the cortical c ...... owth factor receptor silencing
@en
prefLabel
Localization to the cortical c ...... owth factor receptor silencing
@ast
Localization to the cortical c ...... owth factor receptor silencing
@en
P2093
P2860
P356
P1476
Localization to the cortical c ...... owth factor receptor silencing
@en
P2093
Andrea I McClatchey
Annie W Chan
Banumathi K Cole
Marcello Curto
P2860
P304
P356
10.1128/MCB.01139-07
P407
P577
2007-12-17T00:00:00Z