Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
about
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting proteinLatent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding proteinTargeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteinsSynthesis, Processing, and Function of N-glycans in N-glycoproteins.Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor.Phosphorylation of the cation-independent mannose 6-phosphate receptor is closely associated with its exit from the trans-Golgi network.Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartmentDown syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells.Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes.The 46 kDa mannose-6-phosphate receptor contains a signal for basolateral sorting within the 19 juxtamembrane cytosolic residues.Identification of three internalization sequences in the cytoplasmic tail of the 46 kDa mannose 6-phosphate receptor.Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network.Differences in the endosomal distributions of the two mannose 6-phosphate receptors.Restoration of arylsulphatase B activity in human mucopolysaccharidosis-type-VI fibroblasts by retroviral-vector-mediated gene transfer.Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.Four monoclonal antibodies inhibit the recognition of arylsulphatase A by the lysosomal enzyme phosphotransferase.Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages.Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells
P2860
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P2860
Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
description
1990 nî lūn-bûn
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1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
@en
type
label
Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
@en
prefLabel
Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
@en
P2093
P2860
P1433
P1476
Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.
@en
P2093
P2860
P304
P407
P577
1990-11-01T00:00:00Z