The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. - Wikidata - wikimedia - TriplyDB

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

http://www.wikidata.org/entity/Q41301586

about

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3 Ataxin-3 is a multivalent ligand for the parkin Ubl domain Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?RBR E3 ubiquitin ligases: new structures, new insights, new questions The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications Solution structure of the E3 ligase HOIL-1 Ubl domain Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP Trinucleotide repeats: a structural perspective The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.Genes and genetic testing in hereditary ataxias.USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13 Balancing act: deubiquitinating enzymes in the nervous system.Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.Analysis of the GGGGCC Repeat Expansions of the C9orf72 Gene in SCA3/MJD Patients from China.Ubiquitylation of nuclear receptors: new linkages and therapeutic implications.Toward understanding Machado-Joseph disease The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53 Basal and stress-induced Hsp70 are modulated by ataxin-3.Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.Ubiquitin receptors and protein quality control Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells.Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).Regulation of Parkin E3 ubiquitin ligase activity.Posttranslational modification and quality control.Ataxin-3 and its e3 partners: implications for machado-joseph disease.

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P2860

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

http://www.wikidata.org/entity/Q41301586

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

2010年學術文章

@zh

2010年學術文章

@zh-hant

name

The Machado-Joseph disease-ass ...... ubiquitination and stability.

@en

type

label

The Machado-Joseph disease-ass ...... ubiquitination and stability.

@en

prefLabel

The Machado-Joseph disease-ass ...... ubiquitination and stability.

@en

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Human Molecular Genetics

P1476

The Machado-Joseph disease-ass ...... ubiquitination and stability.

@en

P2093

Aislinn J Williams

http://www.w3.org/2001/XMLSchema#string

Ana Djarmati

http://www.w3.org/2001/XMLSchema#string

Henry L Paulson

http://www.w3.org/2001/XMLSchema#string

Lara Fallon

http://www.w3.org/2001/XMLSchema#string

Maria Kontogiannea

http://www.w3.org/2001/XMLSchema#string

Tadeu Fantaneanu

http://www.w3.org/2001/XMLSchema#string

Thomas M Durcan

http://www.w3.org/2001/XMLSchema#string

Thorhildur Thorarinsdottir

http://www.w3.org/2001/XMLSchema#string

P2860

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

Estimation of significance thresholds for genomewide association scans

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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141-154

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scholarly article

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10.1093/HMG/DDQ452

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1

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20

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2010-10-11T00:00:00Z

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47403493

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20940148

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P921

protein ubiquitination

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3005906

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