Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation.
about
Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activityHematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cellsCD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium fluxCD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptorsAnalysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22The motheaten mutation rescues B cell signaling and development in CD45-deficient miceSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsLack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Stimulatory function of paired immunoglobulin-like receptor-A in mast cell line by associating with subunits common to Fc receptors.Alteration of B-cell antigen receptor signaling by CD19 co-ligation. A study with bispecific antibodies.Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms.
P2860
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P2860
Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Hematopoietic cell phosphatase ...... ell antigen receptor ligation.
@en
type
label
Hematopoietic cell phosphatase ...... ell antigen receptor ligation.
@en
prefLabel
Hematopoietic cell phosphatase ...... ell antigen receptor ligation.
@en
P2860
P356
P1476
Hematopoietic cell phosphatase ...... cell antigen receptor ligation
@en
P2093
A C Lankester
G M van Schijndel
P2860
P304
20305-20308
P356
10.1074/JBC.270.35.20305
P407
P577
1995-09-01T00:00:00Z