Critical role of Rho in cell transformation by oncogenic Ras.
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Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligandIQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42HsCDC42 and FGD1 cause distinct signaling and transforming activities.RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitorsRhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damageDistinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signalingThe p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeletonMolecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants.Substrate specificity determinants in the farnesyltransferase beta-subunit.Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiaeRhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cellsRole of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesisRegulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonActivation of the JNK pathway is essential for transformation by the Met oncogeneControl of B cell development by Ras-mediated activation of Raf.Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.Smooth muscle α-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation.Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model.Breast cancer stem cells survive periods of farnesyl-transferase inhibitor-induced dormancy by undergoing autophagy.Simultaneous irradiation of fibroblasts and carcinoma cells repress the secretion of soluble factors able to stimulate carcinoma cell migration.Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction.Critical functions of RhoB in support of glioblastoma tumorigenesisOverexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.TC21 causes transformation by Raf-independent signaling pathways.Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesisInhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parametersRho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901.Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.Rho GTPases modulate malignant transformation of tumor cells.Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element.The RhoB small GTPase in physiology and disease.RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive mannerCell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.
P2860
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P2860
Critical role of Rho in cell transformation by oncogenic Ras.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Critical role of Rho in cell transformation by oncogenic Ras.
@en
type
label
Critical role of Rho in cell transformation by oncogenic Ras.
@en
prefLabel
Critical role of Rho in cell transformation by oncogenic Ras.
@en
P2093
P1433
P1476
Critical role of Rho in cell transformation by oncogenic Ras
@en
P2093
Khosravi-Far R
Lebowitz PF
Prendergast GC
P304
P407
P577
1995-06-01T00:00:00Z